Proteomics

Dataset Information

0

Integrated analysis of the anoikis-related signature identifies RAC3 as a novel therapeutic target in hepatocellular carcinoma

ABSTRACT: Introduction: Anoikis is a form of programmed cell death. Anoikis resistance in hepatocellular carcinoma (HCC) promotes cancer cells shedding from the primary tumor site, thus contributing to survival and distant metastasis. However, the prognostic significance of anoikis-related genes (ARGs) and the biological functions of crucial genes in HCC have not been reported. Objectives: This study aimed to construct a model for predicting the outcome of patients with HCC based on ARGs and to investigate the clinicopathological significance and function of Rac family small GTPase 3 (RAC3) in HCC.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Liver Cancer

SUBMITTER: Dong Wu  

LAB HEAD: Huijie Bian

PROVIDER: PXD057450 | Pride | 2025-05-07

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
NC-1.raw Raw
NC-2.raw Raw
NC-3.raw Raw
PE-1.raw Raw
PE-2.raw Raw
Items per page:
1 - 5 of 8
altmetric image

Publications

Integrated Analysis of the Anoikis-Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor-Promoter Gene in Hepatocellular Carcinoma.

Wu Dong D   Liu Ze-Kun ZK   Sun Ying Y   Gou Chu-Heng CH   Shang Run-Ze RZ   Lu Meng M   Zhang Ren-Yu RY   Wei Hao-Lin HL   Li Can C   Shi Ying Y   Zhang Cong C   Wang Yu-Tong YT   Wei Ding D   Chen Zhi-Nan ZN   Bian Huijie H  

MedComm 20250322 4

Anoikis resistance in hepatocellular carcinoma (HCC) cells boosts survival and metastasis. This study aimed to establish an anoikis-related genes (ARGs)-based model for predicting HCC patients' outcomes and investigate the clinicopathological significance and function of crucial ARGs. The transcriptional expression patterns for HCC cohorts were compiled from TCGA, GEO and ICGC. Univariate and LASSO multivariate analyses were performed to screen for prognostic ARGs. Gain- and loss-of-function stu  ...[more]

Similar Datasets

Transcriptomics Integrated analysis of the anoikis-related signature identifies RAC3 as a novel therapeutic target in hepatocellular carcinoma
2025-03-26 | GSE273947 | GEO
Transcriptomics Microarray analysis of MRC-5 cells infected with Zika virus strains
2021-03-23 | E-MTAB-10292 | biostudies-arrayexpress
Transcriptomics Microarray of cell strain-derived induced pluripotent stem cell
2021-05-27 | E-MTAB-10440 | biostudies-arrayexpress
Transcriptomics Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution
2020-12-31 | E-MTAB-9721 | biostudies-arrayexpress
Transcriptomics Comparative microarray analysis of NaV1.8-expressing DRG neurons and cold-sensitive non-NaV1.8-expressing DRG neurons
2019-07-01 | E-MTAB-7070 | biostudies-arrayexpress
Transcriptomics Effect of milk intake on circulating plasma miRNAs of adult humans
2016-04-06 | E-GEOD-79960 | biostudies-arrayexpress
Transcriptomics Effect of milk intake on circulating PBMC miRNAs of adult humans
2016-04-06 | E-GEOD-79922 | biostudies-arrayexpress
Transcriptomics Microarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
Transcriptomics Microarray data of the subventricular zone and hippocampal tissue from mice exposed to room air or hyperoxia during the neonatal period
2023-01-03 | E-MTAB-11332 | biostudies-arrayexpress
Transcriptomics Gene expression profiling of human whole-blood samples before and after the administration of recombinant human erythropoietin
2021-11-04 | E-MTAB-11080 | biostudies-arrayexpress