Dataset Information
TRF-22 RNA pulldown and Co-IP followed by LC-MS/MS in human cell samples
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Esophagus Squamous Cell Carcinoma
SUBMITTER: 
Xin Qin
LAB HEAD: Ling Pan
PROVIDER: PXD057698 | Pride | 2026-01-12
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Co-IP_FLAG-hnRNPAB.raw | Raw | |||
| Co-IP_FLAG-hnRNPAB.xlsx | Xlsx | |||
| Co-IP_Vector.raw | Raw | |||
| Co-IP_Vector.xlsx | Xlsx | |||
| RNA_Pulldown_KYSE150_tRF-22_Anti-sense.raw | Raw |
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Publications
tRNA-Derived Fragment tRF-22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20251027 1
Small proportions of patients with esophageal squamous cell carcinoma (ESCC) benefit from immune checkpoint blockade therapy, making it urgent to identify factors that limit its effectiveness. It is found that tRF-22, a small RNA derived from tRNA<sup>GlnCTG/TTG</sup>, promotes an immunosuppressive tumor microenvironment. High tRF-22 expression is associated with worse prognosis in ESCC. tRF-22 shapes immunosuppression by increasing polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) ...[more]
