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Human,scalp,dermal papilla cells,LC-MS/MS

ABSTRACT: Three individual patient-originated (Scalp trauma; ages 37, 46 and 57) DPCs were used for the studies. Dermal papilla cells, derived from the frontal scalp of 3 women, were treated with normal medium (Ctrl group) and medium containing 10-7 M corticotropin-releasing hormone (CRH group) for 72 h. Proteins were extracted and digested with trypsin for 4D label-free quantitative proteomics (Shanghai Applied Protein Technology Co., Ltd.).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Cell Culture

SUBMITTER: Wemzi Liang

LAB HEAD: Wenzi Liang

PROVIDER: PXD057745 | Pride | 2025-05-07

REPOSITORIES: Pride

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Publications

Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells.

Liang Wenzi W Chen Xiuwen X Ni Na N Zhuang Chutong C Yu Zhiying Z Xu Ziqing Z Li Yingshi Y Lin Changmin C Huang Keng K

Annals of medicine 20250412 1

<h4>Background</h4>Stress-related hair loss is on the rise, largely due to escalating levels of stress-related corticotropin-releasing hormone (CRH) through poorly defined mechanisms. CRH-mediated activation of corticotropin-releasing hormone receptors (CRHRs) on dermal papilla cells (DPCs) is a likely cause of stress-related hair loss. The aim of the study is to elucidate the key mechanisms of alopecia caused by CRH and provide potential new targets for the treatment of stress-related hair loss ...[more]

PMID: 40219757

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