Dataset Information

Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system

ABSTRACT: Mallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell

SUBMITTER: Keshava Prasad T. S.

LAB HEAD: TSK Prasad

PROVIDER: PXD057783 | Pride | 2025-05-08

REPOSITORIES: Pride

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Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system.

Mallick Sumit S Narayana Vanya Kadla VK Rai Akhila Balakrishna AB Upadhyay Shubham Sukerndeo SS Prasad Thottethodi Subrahmanya Keshava TSK P Sudheer Shenoy SS Bose Bipasha B

The international journal of biochemistry & cell biology 20250408

Cancer stem cells (CSCs) hold a significant role in cancer metastasis, high mortality and severity responsible for therapy resistance and tumour recurrence. The 26S proteasome system plays a major role in protein degradation in normal cells. As most cancers have upregulated 26S proteasome machinery, cancer cells use the 26S proteasome system in their favour for growth support by degrading unwanted proteins, but dysfunction of the 26S proteasome system induces apoptosis in cells. Here, we used he ...[more]

PMID: 40210089

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	CSC_Control_DIA_R1.raw	Raw
	CSC_Control_DIA_R2.raw	Raw
	CSC_Control_DIA_R3.raw	Raw
	CSC_Test_DIA_R1.raw	Raw
	CSC_Test_DIA_R2.raw	Raw