Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system

ABSTRACT: Mallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell

SUBMITTER: Keshava Prasad T. S.  

LAB HEAD: TSK Prasad

PROVIDER: PXD057783 | Pride | 2025-05-08

REPOSITORIES: Pride