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Proteomics analysis of moncytes treated with the HDAC6 inhibitor ITF3756

ABSTRACT: Tumor immunotherapy has revolutionized cancer treatment, particularly through the use of immune checkpoint inhibitors targeting the PD-L1/PD-1 axis. While PD-L1 expression on tumor cells has been established as a predictive biomarker for therapeutic response, emerging evidence highlights the significance of PD-L1 expression on myeloid cells in the periphery and in the tumor microenvironment (TME). This study investigates the effects of the selective HDAC6 inhibitor ITF3756 on PD-L1 expression and on the immune functionality of monocytes stimulated with the pro-inflammatory cytokine TNF-α.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell

SUBMITTER: Roberta Noberini

LAB HEAD: Tiziana Bonaldi

PROVIDER: PXD057931 | Pride | 2025-05-09

REPOSITORIES: Pride

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			Action	DRS
	QEP231227_ItalFarm_A_C1_1.raw	Raw
	QEP231227_ItalFarm_A_C1_2.raw	Raw
	QEP231227_ItalFarm_A_C2_1.raw	Raw
	QEP231227_ItalFarm_A_C2_2.raw	Raw
	QEP231227_ItalFarm_A_C3_1.raw	Raw

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