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The molecular landcape of cellular metal ion hometostasis

ABSTRACT: Protein abundance data from S. cerevisiae cells cultivated in synthetic minimal media with a range of metal concentrations (concentrations of Ca, Cu, Fe, K, Mg, Mn, Na and Zn were changed, one at a time)

INSTRUMENT(S):

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Anja Freiwald

LAB HEAD: Markus Ralser

PROVIDER: PXD057956 | Pride | 2025-06-10

REPOSITORIES: Pride

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			Action	DRS
	20200810_PromegaYE_2ug_SKA.wiff	Wiff
	20200810_PromegaYE_2ug_SKA.wiff.scan	Wiff
	20210225_specspeclib.tsv	Tabular
	DIANN_output.zip	Other
	SKA_202008_EDP_LO_1_A4.wiff	Wiff

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Publications

The molecular landscape of cellular metal ion biology.

Aulakh Simran Kaur SK Lemke Oliver O Szyrwiel Lukasz L Kamrad Stephan S Chen Yu Y Hartl Johannes J Mülleder Michael M Nielsen Jens J Ralser Markus M

Cell systems 20250613 7

Metal ions have crucial roles in cells, but the impact of their availability on biological networks is underexplored. We systematically quantified yeast cell growth and the corresponding metallomic, proteomic, and genetic responses to perturbations in metal availability along concentration gradients of all growth-essential metal ions. We report a remarkable metal concentration dependency of cellular networks, with around half of the proteome, and most signaling pathways such as target of rapamyc ...[more]

PMID: 40516524

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