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Cryo-EM Study of Human Platelet Membrane

ABSTRACT: This is the proteomic analysis data of human platelet membrane solubilized by detergent and assembled into nanodiscs then subjected to cryo-EM study.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Platelet

SUBMITTER: Xu Han

LAB HEAD: Marvin Nieman

PROVIDER: PXD058005 | Pride | 2025-09-29

REPOSITORIES: Pride

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			Action	DRS
	Lum_23jul1912.raw	Raw
	Lum_23jul1913.raw	Raw
	Platelet_membrane_proteins_imputed.xlsx	Xlsx
	checksum.txt	Txt

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Publications

Elucidating the dynamics of integrin αIIbβ3 from native platelet membranes by cryo-EM with build-and-retrieve method.

Han Xu X Zhang Zhemin Z Su Chih-Chia CC Lyu Meinan M Miyagi Masaru M Yu Edward E Nieman Marvin T MT

Blood advances 20250901 18

<h4>Abstract</h4>Platelets fulfill their essential physiological roles sensing the extracellular environment through their membrane proteins. The native membrane environment provides essential regulatory cues that affect the protein structure and mechanism of action. Single-particle cryogenic electron microscopy (cryo-EM) has transformed structural biology by allowing high-resolution structures of membrane proteins to be solved from homogeneous samples. Our recent breakthroughs in data processin ...[more]

PMID: 40472320

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