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Multilevel Proteomic Characterization of Nasopharyngeal Carcinoma in a Chinese Population

ABSTRACT: We collected 102 treatment-naive Nasopharyngeal Carcinoma (NPC) tumors and 62 normal adjacent tissues (NATs) from Chinese patients and conducted multi-level proteomic analysis. A mass spectrometry (MS)-based label-free quantification strategy was adopted for this study. Proteomic and glycoproteomic approaches were carried out on all of the 102 tumors and 62 NATs. Phosphoproteomic analysis was performed on 101 tumors and 53 NATs.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Nasopharyngeal Carcinoma Cell

SUBMITTER: Xinping Chen

LAB HEAD: XinPing Chen

PROVIDER: PXD058041 | Pride | 2025-11-27

REPOSITORIES: Pride

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			Action	DRS
	FE047LPIgB3_NPC_N54.raw	Raw
	FE047LPIgB3_NPC_N55.raw	Raw
	FE047LPIgB3_NPC_N56.raw	Raw
	FE047LPIgB3_NPC_N57.raw	Raw
	FE047LPIgB3_NPC_N58.raw	Raw

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Publications

Covalent binding of 5-tetradecyloxy-2-furoic acid (TOFA) and c(RGDfK) and its co-delivery with Lipusu, a novel synergistic strategy to inhibit the proliferation of nasopharyngeal cancer.

Feng Min M Gong Wei W Zhu Xin X Zhu Juan J Hu Junjie J Xu Weihua W Ma Zhichao Z Fu Shengmiao S Chen Xinping X

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20250412

As the world's only commercially available paclitaxel liposome, Lipusu (Lip) has been clinically used in chemotherapy for >20 years, but the design concept of Lip remains largely unchanged since its initial development. Based on the study of Acetyl-CoA-carboxylase 1 (ACC1) in nasopharyngeal carcinoma (NPC), we proposed the concept of next-generation liposomes (NGL) utilizing lipid demand balance. In this study, we evaluated the feasibility of ACC1 and integrin α<sub>V</sub>β<sub>3</sub> as NPC t ...[more]

PMID: 40228725

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