Dataset Information

Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis

ABSTRACT: Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality.

INSTRUMENT(S): LTQ

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Platelet, Blood Cell

SUBMITTER: Zhao Chen

LAB HEAD: Wang Jianrong

PROVIDER: PXD058230 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	Match_result-X101SC23052248-Z01-J001_B1_43.zip	Other
	Raw_file-X101SC23052248-Z01-J001_B1_43.zip	Other
	checksum.txt	Txt

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Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis.

Li Lei L Zhao Chen C Zhang Ruizhi R Wei Wen W Liu Bowen B Dong Jin J Gao Xueqin X Zhang Di D Wang Xueqing X Lu Meilin M Zhang Yumu Y Yu Yao Y Yuan Na N Xu Youjia Y Wang Jianrong J Fang Yixuan Y

Bone research 20250303 1

The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains largely elusive. Using conditional gene knockout mouse models, we demonstrated that loss of Beclin 1 (Becn1), a major regulator of mammalian autophagy, exclusively in the megakaryocytic lineage disrupted autophagy in platelets but did not compromise megakaryopoiesis or the formation and function of platelets. Unexpectedly, conditional Becn1 deletion in male mice led to a remarkabl ...[more]

PMID: 40032858

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