Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis

ABSTRACT: Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Platelet, Blood Cell

SUBMITTER: Zhao Chen  

LAB HEAD: Wang Jianrong

PROVIDER: PXD058230 | Pride | 2025-05-07

REPOSITORIES: Pride