Proteomics of Hypothalamic Extracellular Vesicles at the Onset of Obesity

ABSTRACT: This proteomics dataset profiles hypothalamic extracellular vesicles (hEVs) during the early stages of diet-induced leptin resistance. Using next-generation proteomics in a discovery-driven approach, hEVs were analyzed from a hamster model subjected to a high-fat diet (HFD) for 30 days. The dataset captures alterations in hEV protein composition linked to disrupted cellular metabolism, neurodegeneration, and metabolic disorders, providing molecular evidence of early obesity-associated dysfunction.

INSTRUMENT(S):

ORGANISM(S): Mesocricetus Auratus (golden Hamster)

TISSUE(S): Brain

DISEASE(S): Obesity

SUBMITTER: Aida Serra  

LAB HEAD: Aida Serra

PROVIDER: PXD058280 | Pride | 2025-06-23

REPOSITORIES: Pride