Dataset Information

Proteomics of Hypothalamic Extracellular Vesicles at the Onset of Obesity

ABSTRACT: This proteomics dataset profiles hypothalamic extracellular vesicles (hEVs) during the early stages of diet-induced leptin resistance. Using next-generation proteomics in a discovery-driven approach, hEVs were analyzed from a hamster model subjected to a high-fat diet (HFD) for 30 days. The dataset captures alterations in hEV protein composition linked to disrupted cellular metabolism, neurodegeneration, and metabolic disorders, providing molecular evidence of early obesity-associated dysfunction.

INSTRUMENT(S):

ORGANISM(S): Mesocricetus Auratus (golden Hamster)

TISSUE(S): Brain

DISEASE(S): Obesity

SUBMITTER: Aida Serra

LAB HEAD: Aida Serra

PROVIDER: PXD058280 | Pride | 2025-06-23

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	160817_HFD_Exp_EVsB_C2_01.raw	Raw
	160817_HFD_Exp_EVsB_C2_02.raw	Raw
	160817_HFD_Exp_EVsB_C2_03.raw	Raw
	160817_HFD_Exp_EVsB_C2_04.raw	Raw
	160817_HFD_Exp_EVsB_C2_05.raw	Raw

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Publications

Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity.

Fernández-Rhodes María M Suárez Manuel M Molet Itziar I Suárez-García Susana S Arola Lluís L Sze Siu Kwan SK Gallart-Palau Xavier X Serra Aida A

ACS omega 20250529 22

The onset of obesity is characterized by early physiological and molecular changes, including leptin resistance and hypothalamic dysfunction, preceding significant weight gain and metabolic complications. Extracellular vesicles (EVs) are key mediators of intercellular communication, reflecting early pathological shifts in metabolic disorders. This study investigates the role of hypothalamic EVs (hEVs) in early obesogenic insult and their potential implications for obesity-related comorbidities. ...[more]

PMID: 40521556

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