Dataset Information
SYP-4 phosphoproteomics characterization
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Gonad, Germ Cell Nucleus
SUBMITTER: 
Frank Stein
LAB HEAD: Simone Koehler
PROVIDER: PXD058372 | Pride | 2025-05-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| F088900.dat | Other | |||
| F088902.dat | Other | |||
| F089950.dat | Other | |||
| F089953.dat | Other | |||
| F089955.dat | Other |
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Publications
Crossovers are regulated by a conserved and disordered synaptonemal complex domain.
Nucleic acids research 20250201 4
During meiosis, the number and distribution of crossovers (COs) must be precisely regulated through CO assurance and interference to prevent chromosome missegregation and genomic instability in the progeny. Here we show that this regulation of COs depends on a disordered and conserved domain within the synaptonemal complex (SC). This domain is located at the C-terminus of the central element protein SYP-4 in Caenorhabditis elegans. While not necessary for synapsis, the C-terminus of SYP-4 is cru ...[more]
