CENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos

ABSTRACT: This project focused on the identification of phosphorylation sites on the C. elegans inner kinetochore protein CENP-C and the outer kinetochore complex MIS12. Phosphorylation was carried out in vitro using recombinant proteins. CENP-C was phosphorylated with Cdk1, PLK-1 or both; MIS12 complex components phosphorylation was performed using PLK-1.

INSTRUMENT(S):

ORGANISM(S): Caenorhabditis Elegans

SUBMITTER: Douglas Lamont  

LAB HEAD: Dr Fede Pelisch

PROVIDER: PXD058379 | Pride | 2024-11-28

REPOSITORIES: Pride