Dataset Information

BMDM mouse ctrl SPM (label free proteomics)

ABSTRACT: This project investigates the proteomic changes in bone marrow-derived macrophages (BMDMs) from mouse under two conditions: control (Ctrl) and specialized pro-resolving mediator (SPM) treatment. The study includes 3 biological replicates per condition, aiming to identify proteins involved in macrophage function and inflammation resolution.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Macrophage

DISEASE(S): Pancreatic Cancer

SUBMITTER: Hanshen Yang

LAB HEAD: Hanshen Yang

PROVIDER: PXD058466 | Pride | 2025-09-01

REPOSITORIES: Pride

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	Database.zip	Other
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Publications

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.

Yang Hanshen H Zhang Xiaozhen X Zhang Sirui S Yang Yanqing Y Chen Yan Y Jiang Yangwei Y Lu Qingsong Q Liu Lingyue L Lao Mengyi M Du Weiran W Sun Kang K He Lihong L Shi Jiatao J Liu Xinyuan X Song Jinyuan J Lu Na N Huang Junming J Huang Jinyan J Zhou Ruhong R Lu Xiongbin X Liang Tingbo T Bai Xueli X

Nature communications 20250822 1

While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients reveals that spermine levels are significantly elevated and correlate with poor prognosis. Using a multi-omics approach, we identify Serpinb9 as a vulnerability in spermine metabolism in pancreatic cancer. Serpinb9, a serine protease inhibitor, ...[more]

PMID: 40846845

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