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Targeted mass spectrum on activation-state-dependent Integrin alpha 5

ABSTRACT: Integrin alpha 5 is a key transmembrane protein that mediates cell-ECM adhesion and ECM assembly. Its activation and signaling involve both cytoplasmic and extracellular proteins. Using zebrafish somitogenesis as the physiological setting, we sought to identify activation-state-dependent Integrin alpha 5 (Itga5) associated proteins.

INSTRUMENT(S):

ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)

TISSUE(S): Embryo

SUBMITTER: Guangyu SUN

LAB HEAD: Guangyu Sun

PROVIDER: PXD058550 | Pride | 2025-10-13

REPOSITORIES: Pride

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			Action	DRS
	20230905_SGY_SG-D2_PRM.raw	Raw
	20230905_SGY_SG-D3_PRM.raw	Raw
	20230905_SGY_SG-D4_PRM.raw	Raw
	20230905_SGY_SG-E1_PRM.raw	Raw
	20230905_SGY_SG-E2_PRM.raw	Raw

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1 - 5 of 17

Publications

Actn4 Links Inactive Integrin α5 With Actin in Zebrafish Somites.

Sun Guangyu G Holley Scott A SA

Molecular & cellular proteomics : MCP 20251008 2

Integrins are key plasma membrane proteins that mediate cell-ECM adhesion and communication, and they rely on a conformational change for their activation and bidirectional signaling. However, there are few in vivo studies of integrin activation. Here, we identify Integrin α5 (Itgα5)-associated proteins in the physiological setting of zebrafish somite morphogenesis. Using label-free mass spectrometry, we compared Itgα5-associated proteins in different integrin activation states. As expected, we ...[more]

PMID: 41072919

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