Dataset Information

Widespread telomere bacteriophages equip their hosts with potent inter-bacterial weapons

ABSTRACT: Bacteriophage (phage) are viruses that can kill bacteria, but also mediate gene transfer for bacterial evolution. The telomere phages are a curious form using telomere-like structures to replicate their genomes as linear extrachromosomal elements. Here we find that telomere phages are widely distributed in bacteria, being highly prevalent in Klebsiella species. We established a model system to investigate telomere phage biology and find only a small set of phage proteins are expressed in phage-host cells, including a toxin – telocin - that kills other Klebsiella strains. We identify and validate other telocins in the genomes of other, widespread Klebsiella telomere phages. Thus, telomere phages are widespread elements encoding diverse antibacterial weapons and we discuss the prospect of using telocins for precision editing of microbial populations.

INSTRUMENT(S):

ORGANISM(S): Klebsiella Variicola Subsp. Variicola

SUBMITTER: Ralf Schittenhelm

LAB HEAD: Trevor Lithgow

PROVIDER: PXD058604 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	HF1DS20210512_SallyB_01.raw	Raw
	HF1DS20210512_SallyB_02.raw	Raw
	HF1DS20210512_SallyB_03.raw	Raw
	HF1DS20210512_SallyB_04.raw	Raw
	HF1DS20210512_SallyB_05.raw	Raw

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Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons.

Byers Sally M H SMH Rocker Andrea A Nguyen To N T TNT Rosas Natalia C NC Taiaroa George G Tan Kher Shing KS Li Yan Y Wilksch Jonathan J JJ Steele Joel R JR Schittenhelm Ralf B RB Dunstan Rhys A RA Short Francesca L FL Lithgow Trevor T

Science advances 20250430 18

Bacteriophages (phages) are viruses that can kill bacteria, thereby editing and shaping microbial communities. The telomere phages are a curious form using telomere-like structures to replicate their genomes as linear extrachromosomal elements. Here, we find that telomere phages are widely distributed in bacteria, being highly prevalent in <i>Klebsiella</i> species. We establish a model system to investigate telomere phage biology by isolating the virions of telomere phages and infecting naïve s ...[more]

PMID: 40305614

Dataset Information

Widespread telomere bacteriophages equip their hosts with potent inter-bacterial weapons

Dataset's files

Publications

Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons.

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