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Multi-omics analysis combined with the Nephroseq database reveals that FN1 and three other genes are closely related to renal function in diabetic nephropathy.

ABSTRACT: Diabetic nephropathy is a serious late chronic complication of type 2 diabetes and a major cause of end-stage renal disease. In order to better understand the molecular mechanisms of kidney lesions, we examined the mRNA and protein levels of mouse kidney to reveal the changes occurring in the kidney tissue of diabetes-associated kidney injury at the molecular level, to provide a theoretical basis for drug treatment.

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ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

TISSUE(S): Kidney

SUBMITTER: ling deng

LAB HEAD: First Name: Ling ,Last Name: Deng

PROVIDER: PXD058790 | Pride | 2025-10-20

REPOSITORIES: Pride

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Publications

Multi-Omics Analysis and Nephroseq Database of Genes Related to Kidney Function in Diabetic Nephropathy Patients to Predict Potential Target Drugs.

Deng Ling L Yan Feifan F Feng Changmei C Yang Qiong Q

Diabetes, metabolic syndrome and obesity : targets and therapy 20251006

<h4>Purpose</h4>Diabetic nephropathy (DN), a major complication of type 2 diabetes and leading cause of end-stage renal disease, lacks complete molecular understanding. To elucidate the mechanisms underlying kidney injury in DN, we analyzed mRNA and protein expression changes in mouse kidney tissue, aiming to provide a theoretical foundation for drug development.<h4>Methods</h4>C57BL/6 mice were divided into two groups: a normal control group and a diabetes model group. The type 2 diabetes model ...[more]

PMID: 41078586

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