Proteomics

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Proteogenomic landscape of chemoradiation resistant cervical cancer patients from India: Unveiling novel therapeutic targets

ABSTRACT: Cervical cancer is one of the leading causes of cancer related deaths among females. Due to absence of proper screening programmes, most of the cervical cancer cases are presented in the locally advanced stage of the disease. Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer. However, resistance to CCRT limit the success of the treatment regimen. In this study, we investigated the altered proteome of CCRT resistant and sensitive cohort using Mass spectrometry-based proteomics. We carried out proteomic analysis of treatment naïve cervical cancer patients whose response to CCRT is recorded. The proteomic analysis revealed altered proteins and potential predictive biomarkers associated with CCRT resistance in cervical cancer patients.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cervical Carcinoma Cell, Epithelial Cell Of Cervix

DISEASE(S): Cervix Carcinoma

SUBMITTER: Irene A George  

LAB HEAD: Prashant Kumar

PROVIDER: PXD058817 | Pride | 2026-04-06

REPOSITORIES: Pride

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CRC_RN_1.raw Raw
CRC_RN_10.raw Raw
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Publications

Cervical cancer is highly prevalent in India, with most cases being diagnosed at advanced stages. Despite the standard concurrent chemoradiotherapy (CCRT), 30-40% of patients' experience treatment failure, underscoring the need for improved therapeutic strategies. Understanding resistance mechanisms and identifying predictive biomarkers are crucial to improve treatment efficacy and enable personalized medicine. We conducted a comprehensive genomic and proteomic analysis to identify molecular sig  ...[more]

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