Proteomics

Dataset Information

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TMT proteomics of Cmtr1 cKO naive CD4 T cells

ABSTRACT: We aim to find the gene-specific effects of Cmtr1 KO in mouse CD4 T cells. TMT proteomics datasets were generated to find out which proteins are dependent on Cmtr1 for their expression.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): T Cell, Lymph Node

SUBMITTER: Alison Galloway  

LAB HEAD: Victoria H. Cowling

PROVIDER: PXD058819 | Pride | 2025-10-16

REPOSITORIES: Pride

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Publications

CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms.

Galloway Alison A   Knop Katarzyna K   Gomez-Moreira Carolina C   Xavier Vanessa V   Thomson Sarah S   Yoshikawa Harunori H   Suska Olga O   Lukoszek Radoslaw R   Kaskar Aneesa A   Lamond Angus I AI   MacVicar Thomas T   Cowling Victoria H VH  

Cell reports 20251013 10

During T cell activation, mitochondrial biogenesis and cellular metabolism are altered to meet the elevated energy demands of protein synthesis, rapid proliferation, and effector T cell function. The mechanisms coupling mitochondrial dynamics to T cell status are unclear. Here, we report that RNA cap methyltransferase 1 (CMTR1) is induced in activated T cells, methylating the first nucleotide on mRNA and U2 small nuclear RNA (snRNA), a component of the spliceosome. Using transcriptomic analyses,  ...[more]

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