Dataset Information

Gestational age-dependent proteome changes in amniotic fluid extracellular vesicles

ABSTRACT: This study isolated and analysed extracellular vesicles from human amniotic fluid derived from routine second-trimester amniocentesis and elective Caesarean section at term. Label-free proteomics identified 4137 proteins with high confidence.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Amniotic Fluid

SUBMITTER: Ishara Atukorala

LAB HEAD: Lisa Hui

PROVIDER: PXD058882 | Pride | 2025-06-23

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	231010AFEVsTermvs2ndTrimester.tsv	Tabular
	231012AFEVsTermvs2ndTrimester.sps	Other
	AFEVs2ndtrimester1.raw	Raw
	AFEVs2ndtrimester2.raw	Raw
	AFEVs2ndtrimester3.raw	Raw

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Publications

Amniotic Fluid Extracellular Vesicle Properties Evolve With Gestational Age and Reflect Fetal Development.

Atukorala Ishara I Beard Sally S Ang Ching-Seng CS Brown Hamish H Raghavan Swetha S de Alwis Natasha N Fato Bianca B Binder Natalie N Hannan Natalie N Hui Lisa L

Journal of extracellular biology 20251008 10

Amniotic fluid (AF) is a valuable source of extracellular vesicles (EVs) derived from the fetoplacental unit. Preclinical and clinical studies have highlighted promising applications of AF-EVs and their role in cellular communication, yet our understanding of AF-EV physiology remains limited. This study aimed to examine the physiological importance of AF-EVs in fetal development from the second trimester to term gestation. We obtained AF samples from routine second-trimester amniocentesis and pr ...[more]

PMID: 41078592

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