An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways

ABSTRACT: An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling pathways downstream of ADAM9, including the oncogenic mTOR and tumor suppressor FOXO pathways.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Congyu Lu  

LAB HEAD: Shuo Wei

PROVIDER: PXD059109 | Pride | 2026-04-13

REPOSITORIES: Pride