Dataset Information

An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways

ABSTRACT: An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling pathways downstream of ADAM9, including the oncogenic mTOR and tumor suppressor FOXO pathways.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Congyu Lu

LAB HEAD: Shuo Wei

PROVIDER: PXD059109 | Pride | 2026-04-13

REPOSITORIES: Pride

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An Integrative Proteotranscriptomics Approach Reveals New ADAM9 Substrates and Downstream Pathways.

Lu Congyu C Xu Xiaolu X Sindhu Neha N Rainey Jessica J Zhang Yuhan Y Polson Shawn W SW Qiu Jing J Wei Shuo S

Molecular & cellular proteomics : MCP 20260223 4

A Disintegrin And Metalloproteinase 9 (ADAM9) is a cell-surface protease that can shed the ectodomain of membrane protein substrates. Dysregulated ADAM9 activity has been implicated in several diseases, such as solid tumors, autoimmunity, inflammatory diseases, and coronavirus disease 2019. Despite its importance, the substrates and targets of ADAM9 in normal and pathological processes are poorly understood. Here, we developed an integrative proteotranscriptomics approach to systematically ident ...[more]

PMID: 41740737

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			Action	DRS
	Wei_120920.sf3	Other
	Wei_120920_SF01.mzML	Mzml
	Wei_120920_SF02.mzML	Mzml
	Wei_120920_SF03.mzML	Mzml
	Wei_120920_SF04.mzML	Mzml