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The proteomics of mice granulosa cells

ABSTRACT: In this study, the samples were subjected to quantitative proteomic studies through the application of a series of cutting-edge techniques, including protein extraction, enzyme digestion, liquid chromatography-mass spectrometry tandem analysis, and bioinformatic analysis.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Ovary

SUBMITTER: Gang Wu

LAB HEAD: Gang Wu

PROVIDER: PXD059159 | Pride | 2025-09-29

REPOSITORIES: Pride

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Publications

Lactylation of CREB is required for FSH-induced proliferation and differentiation of ovarian granulosa cells.

Wu Gang G Chen Min M He Tong T Pan Yitong Y Li Chengyu C Liu Zhaojun Z Li Hongmin H Sheng Yanan Y Dai Weilong W Shen Ming M Liu Honglin H

Nucleic acids research 20250901 17

Follicle-stimulating hormone (FSH) promotes follicular development by inducing the proliferation and differentiation of granulosa cells (GCs). This process is primarily attributed to the activation of the canonical G protein-coupled receptor (GPCR)/adenylyl cyclase/cAMP/PKA/CREB signaling pathway. Here, we revealed a novel mechanism wherein FSH promotes GCs proliferation and differentiation by stimulating cAMP response element-binding protein (CREB) lactylation. Specifically, FSH induced CREB la ...[more]

PMID: 40966521

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2024-04-05 | PXD046507 | Pride

Crotonylomics sequencing of human non small cell lung cancer cell lines

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Succinylation proteome analysis of Cd-exposed Neuro-2a cells

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The lactylome of mice granulosa cells

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2025-09-29 | PXD059168 | Pride

Analysis of cryopreservation of human granulosa cells

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