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Proteomics exploration of the human PTGR2 interactome

ABSTRACT: Exploring the interactome of human PTGR2 by MS-based proteomics.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Renal Cell Carcinoma

SUBMITTER: Wei Chang

LAB HEAD: Zhongjin Yue

PROVIDER: PXD059160 | Pride | 2025-07-28

REPOSITORIES: Pride

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Publications

Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma.

Chang Wei W Zhang Biao B Yang Shujun S Zhang Xingxing X Zhang Lili L Zhang Su S Lu Jianzhong J Wang Wei W Shang Panfeng P Yue Zhongjin Z

Scientific reports 20250719 1

Acquired and intrinsic resistance to sunitinib is a major obstacle to improving the therapeutic efficacy of treatment for clear cell renal cell carcinoma (ccRCC). This study aimed to identify novel therapeutic targets and the potential molecular mechanisms to overcome sunitinib resistance in ccRCC. Utilizing genome-wide CRISPR/Cas9 screening and resistant transcriptomics, we identified that prostaglandin reductase 2 (PTGR2) is a novel therapeutic target to overcome sunitinib resistance in ccRCC. ...[more]

PMID: 40683967

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