Assessment of CDK4 as a serine kinase phosphorylating OGG1

ABSTRACT: The early studies showed the serine/threonine of OGG1 was phosphorylated by CDK4 in vitro, in our study, LC-MS/MS was performed, and Byonic engine was used to identify the precise site to be phosphorylated by CDK4.The present study discovered a high basal level of CDK4-mediated phosphorylation of OGG1 at S326, and this modification undergoes decline to resume a higher affinity with DNA for facilitating the role of OGG1 in gene transcription.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Jinling Han  

LAB HEAD: Professor Xueqing Ba

PROVIDER: PXD059565 | Pride | 2025-04-18

REPOSITORIES: Pride