Dataset Information

SEPT9 APMS from DLD-1 cells associated with intestinal epithelium

ABSTRACT: Co-IP and tryptic digestion of SEPT9 pulldowns from DLD-1 cells

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Malignant Cell, Cell Culture

DISEASE(S): Crohn's Colitis,Ulcerative Colitis,Colon Cancer

SUBMITTER: Erin Jeffery

LAB HEAD: Seham Ebrahim

PROVIDER: PXD059782 | Pride | 2025-09-29

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	230526_Sept9_DDA_HCDorbi_120min_PD_SearchWithRab11b.mzid	Mzid
	230526_Sept9_DDA_HCDorbi_120min_PD_SearchWithRab11b.pdResult	Other
	230526_Sept9_v1v2v5_BioRep123_TechRep12_PD_SearchWithRab11b_Peptides.xlsx	Xlsx
	230526_Sept9v1_Rep1_HCDorbi_90min_Run1.msf	Msf
	230526_Sept9v1_Rep1_HCDorbi_90min_Run1.raw	Raw

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Publications

The septin cytoskeleton is a regulator of intestinal epithelial barrier integrity and mucosal inflammation.

Naydenov Nayden G NG Hu Gaizun G Robak Dominik D Zafar Atif A Makhmudova Khosiyat K Lechuga Susana S Ohno Yuta Y Sangwan Naseer N Bandyopadhyay Saikat S Musich Ryan R Jeffery Erin E Sun Lei L Marino-Melendez Armando A Rieder Florian F Sheynkman Gloria G Ivanov Andrei I AI Ebrahim Seham S

JCI insight 20251007 22

Intestinal epithelial barrier integrity is essential for human health, and its disruption induces and exacerbates intestinal inflammatory disorders. While the epithelial cytoskeleton is critical for maintaining gut barrier-integrity, the role of septins - a family of GTP-binding, cytoskeletal proteins - is largely unknown. This highlights an important knowledge gap, as dysfunction of septins, and specifically septin 9 (SEPT9), is associated with intestinal pathologies. We determined that SEPT9 l ...[more]

PMID: 41055961

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