Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Barbara Steigenberger
LAB HEAD: Matthias J. Feige
PROVIDER: PXD059792 | Pride | 2025-08-25
REPOSITORIES: Pride
Items per page: 1 - 5 of 15 |
Nature communications 20250802 1
Structure formation of membrane proteins is error-prone and thus requires chaperones that oversee this essential process in cell biology. The ER membrane protein complex (EMC) is well-defined as a transmembrane domain (TMD) insertase. In this study, we characterize an additional chaperone function of the EMC. We use interactomics and systematic studies with model proteins to comprehensively define client features for this EMC chaperone mode. Based on this data, we develop a machine learning-base ...[more]