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Human synovium regional proteomics analysis

ABSTRACT: To analyze regional expression differences of proteins in human synovium

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Synovium

SUBMITTER: lin zhu

LAB HEAD: zhu lin

PROVIDER: PXD059875 | Pride | 2025-10-13

REPOSITORIES: Pride

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Publications

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression.

Zhu Lin L Diao Xin X Yuan Chenrui C Lau Chun Man Lawrence CML Wang Jianing J Wu Wenlong W Mobasheri Ali A Houard Xavier X Wen Chunyi C Cai Zongwei Z

Theranostics 20250830 18

<b>Rationale</b>: Synovial fibrosis, driven by myofibroblast activation and extracellular matrix remodelling, is fundamental in osteoarthritis (OA) pathogenesis but remains poorly understood due to the spatial heterogeneity of synovial inflammation (synovitis). Accurate molecular endotyping of synovial inflammation is essential for effective treatment of OA given its multifactorial nature, yet it requires integrating multiple layers of information with spatial context due to the significant hete ...[more]

PMID: 41041046

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