Dataset Information

Ovarian cancer cell line landscape

ABSTRACT: Nine ovarian cancer cell lines were analyzed using phosphoproteomics and proteomics. The KURAMOCHI cell line was further subjected to treatment with the drug C26A6 and transfection with siRNA towards MTDH and SND1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Fredrik Levander

LAB HEAD: Fredrik Levander

PROVIDER: PXD059892 | Pride | 2025-10-29

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	220516_EV1109_LW_A2780_S19.raw	Raw
	220516_EV1109_LW_A2780_S20.raw	Raw
	220516_EV1109_LW_A2780_S21.raw	Raw
	220516_EV1109_LW_A2780_S22.raw	Raw
	220516_EV1109_LW_A2780_S23.raw	Raw

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Publications

Proteomics discovery of MTDH and SND1 interaction vulnerabilities in ovarian cancer.

Esmaeili Parisa P Nasimian Ahmad A Werner Lucas L Junior Sergio Mosquim SM Jakobsson Magnus E ME Gerdtsson Anna Sandström AS Kazi Julhash U JU Levander Fredrik F

Scientific reports 20251124 1

High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive subtype of ovarian cancer. The combination of late-stage diagnosis and the tendency to exhibit resistance to existing treatments highlights a critical gap in effective therapeutic options. There is thus a need for novel strategies for targeting HGSOC, particularly in its advanced stages. To address this gap, we developed a comprehensive atlas profiling both the proteome and phosphoproteome levels across a panel of nine ...[more]

PMID: 41286067

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