Probing downstream effects of ALK and ROS1 fusion oncogenes in Glioma using proteomics

ABSTRACT: To identify targets of aberrantly expressed RTK-fusion oncogenes, serine/threonine and tyrosine phosphorylation signatures in transgenic cells lines expressing different RTK-fusion oncogenes were compared with their respective kinasedead mutant counterparts. Comparing the differentially phosphorylated proteins between the different RTK fusions were used to identify commonly deregulated pathways as well as pathways specifically targeted by individual RTK-fusions.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Brain Glioma

SUBMITTER: Ana Sofia Guerreiro Stücklin  

LAB HEAD: Ana Sofia

PROVIDER: PXD059984 | Pride | 2026-01-22

REPOSITORIES: Pride