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JNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation

ABSTRACT: JNKs play critical roles in neuronal damage associated with neurodegenerative disease and inhibitors of JNK1 have shown anxiolytic and anti-depressive effects in mice. In this study, we analyze the phosphoproteomes of hippocampus and nucleus accumbens in mice treated with DJNKI-1, a JNK inhibitor.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Dani Flinkman

LAB HEAD: Eleanor Coffey

PROVIDER: PXD060057 | Pride | 2025-12-02

REPOSITORIES: Pride

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			Action	DRS
	151026_VS_10DH_1.RAW	Raw
	151026_VS_10TH_1.RAW	Raw
	151026_VS_1TH_1.RAW	Raw
	151026_VS_3TH_1.RAW	Raw
	151026_VS_4DH_1.RAW	Raw

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JNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation.

Hong Ye Y Siino Valentina V Flinkman Dani D Deshpande Prasannakumar P Martinez Sylvia Ortega SO Fagerholm Veronica V Varidaki Artemis A Heemeryck Pierre P Sourander Christel C James Peter P Coffey Eleanor E

Neurobiology of disease 20251129

c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo on protein phosphorylation in the brain remain largely unknown. This study aimed to (1) determine how chronic JNK inhibition altered proteome-wide phosphorylation in hippocampus and nucleus accumbens, regions central to affective processing, and (2) determine which JNK-regulated phosphoproteins were associat ...[more]

PMID: 41319756

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