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Effect of Small Molecules in Zebrafish Caudal Fin Regeneration

ABSTRACT: The study analysed proteomic changes during zebrafish caudal fin tissue regeneration post small molecule treatment.

INSTRUMENT(S):

ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)

TISSUE(S): Tail Fin

SUBMITTER: Mohammed Idris

LAB HEAD: Mohammed M Idris

PROVIDER: PXD060144 | Pride | 2025-11-24

REPOSITORIES: pride

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			Action	DRS
	ECS-QE-2C3M-15CM-F0H-1-90min-18-05-2023-ANUSHA.mzML	Mzml
	ECS-QE-2C3M-15CM-F0H-1-90min-18-05-2023-ANUSHA.raw	Raw
	ECS-QE-2C3M-15CM-F0H-2-90min-18-05-2023-ANUSHA.mzML	Mzml
	ECS-QE-2C3M-15CM-F0H-2-90min-18-05-2023-ANUSHA.raw	Raw
	ECS-QE-2C3M-15CM-F0H-3-90min-18-05-2023-ANUSHA.mzML	Mzml

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Publications

Proteomic Insights into Small Molecule Modulation on Caudal Fin Regeneration in Zebrafish.

Anusha P V PV Tewari Shailvi S Philip Catherine C Arvind Anushka A Iyoob Ifra I Idris Mohammed M MM

ACS omega 20251027 44

Dietary and addictive small molecules play a significant role in altering <i>in vivo</i> conditions. Due to their minuscule size, these molecules can seamlessly traverse tissues and cellular membranes, influencing key biological processes such as cellular growth, differentiation, and intracellular communication, which are crucial for tissue regeneration. The zebrafish serves as an excellent model for studying regenerative growth due to its remarkable ability to regrow amputated appendages. In th ...[more]

PMID: 41244470

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Project description:Zebrafish have the remarkable ability to regenerate body parts including the heart, spinal cord and fins by a process referred to as epimorphic regeneration. Recent studies have illustrated that similar to adult zebrafish, early life stage-larvae also possess the ability to regenerate the caudal fin. A comparative genomic analysis was used to determine the degree of conservation in gene expression among the regenerating adult caudal fin, adult heart and larval fin. Results indicate that these tissues respond to amputation/injury with strikingly similar genomic responses. Comparative analysis revealed raldh2, a rate-limiting enzyme for the synthesis of Retinoic acid (RA), as one of the highly induced genes across the three regeneration platforms. Experiment Overall Design: The caudal fin of zebrafish larvae at 2days post fertilization were amputated. Caudal fin tissue at 2dpf and regenerating fins were isolated at 1, 2and 3 days post amputation. Three replicates were collected at each time point. 150 fins were pooled to comprise one replicate.

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Gene expression data from time course of fin regeneration in Danio rerio (part 1)

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