Proteomics

Dataset Information

A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

ABSTRACT: Cereblon (CRBN) is a ubiquitin ligase widely harnessed for targeted protein degradation. We report the discovery of a molecular glue that drives CRBN homo-dimerization and subsequent fast, potent, and selective CRBN degradation by the ubiquitin proteasome system. The structure of the complex reveals a unique mechanism whereby two molecular glues assemble into a helix-like structure and drive ternary complex formation by mimicking a protein degron in trans.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Jurkat Cell

SUBMITTER: Despoina Kapsitidou  

LAB HEAD: Debora Bonenfant

PROVIDER: PXD060261 | Pride | 2025-09-08

REPOSITORIES: Pride

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PX_DEG_00497_2024_ECL02_MS3_Aurora_Fct.mzML Mzml
PX_DEG_00497_2024_ECL02_MS3_Aurora_Fct.mzid Mzid
PX_DEG_00497_2024_ECL02_MS3_Aurora_Fct01_0741.raw Raw
PX_DEG_00497_2024_ECL02_MS3_Aurora_Fct02_0742.raw Raw
PX_DEG_00497_2024_ECL02_MS3_Aurora_Fct03_0743.raw Raw
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