Proteomics

Dataset Information

0

Impact of FGF-2 and FGF-2 containing cell culture supernatants on the intracellular protein composition of ReNcell derived neuron

ABSTRACT: FGF-2 is an important protein involved in a vast number of molecular pathways and a number of cellular functions including glial cell differentiation and response to axon injury. This protein was found to be present significantly in supernatants of female derived murine oligodendrocyte progenitor cells (OPC) that have been maintained under hyperoxic conditions. Therefore, this protein might be important in protecting the brain against oxidative stress. Functional assays on neuronal cells in the presence of FGF-2 or OPC culture supernatants were performed and findings related to the impact of the treatment conditions on the intracellular protein response of ReNcell derived neurons were reported.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Elke Hammer  

LAB HEAD: Dr. Elke Hammer

PROVIDER: PXD060285 | Pride | 2025-09-29

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20240524_Exp_AW_Neona_11_F_3_3.raw Raw
20240524_Exp_AW_Neona_12_F_3_4.raw Raw
20240524_Exp_AW_Neona_13_F_80_1.raw Raw
20240524_Exp_AW_Neona_14_F_80_2.raw Raw
20240524_Exp_AW_Neona_15_F_80_3.raw Raw
Items per page:
1 - 5 of 18
altmetric image

Publications

Sex-Specific Differences in the Secretome of Oligodendrocyte Progenitor Cells Post Hyperoxic Stress.

Sunny Donna Elizabeth DE   Hammer Elke E   Michalik Stephan S   Völker Uwe U   Heckmann Matthias M  

Journal of extracellular biology 20250923 9

Cerebral oxygenation differences in the neonatal period of human preterm infants, along with sex-specific differences in combating oxidative stress, can lead to disruption of normal oligodendrocyte maturation and function, which in turn can differentially affect neuronal development and activity in the male and female brains. Secretory proteins and extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication and stress response in the brain. Our  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of human fibroblasts stimulated with PDGF-BB or b-FGF
2009-03-20 | E-GEOD-14256 | biostudies-arrayexpress
Proteomics Profiling of Y1 cells treated with FGF-2 reveals parallels with oncogene-induced senescence
2021-06-16 | PXD020688 | Pride
Transcriptomics Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination (RNA-Seq of differentiated NSC after lnc-OPC knockdown)
2015-11-04 | E-GEOD-74647 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Xenopus embryos in which fibroblast growth factor (FGF) signalling was inhibited by two different dominant negative FGF receptors
2009-03-01 | E-MEXP-2058 | biostudies-arrayexpress
Transcriptomics Fibroblast growth factor 9 inhibits remyelination via an off target effect on astrocytes in multiple sclerosis
2016-02-17 | E-GEOD-44562 | biostudies-arrayexpress
Transcriptomics Transcription profiling of orthoptic PC-3/FGF-8b- and PC-3/mock-transfected prostate tumors in nude mice
2008-03-04 | E-MEXP-1081 | biostudies-arrayexpress
no omics defined Transcription profiling of human PC3 prostate cells transfected with FGF-8b vs control vector
2009-06-01 | E-MEXP-581 | biostudies-arrayexpress
Transcriptomics RNA-seq of human mesenchymal stromal cells cultured in PEG hydrogels with and without FGF-2
2020-06-02 | E-MTAB-8510 | biostudies-arrayexpress
Transcriptomics Transcription profiling of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation)
2006-03-15 | E-TABM-39 | biostudies-arrayexpress
Proteomics LPC 18:1 protein interaction (OPC)
2022-02-17 | PXD025175 | Pride