ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche

ABSTRACT: Spontaneously transformed mouse ovarian surface epithelial cell line ID8 generates a syngeneic mouse model, frequently used in pre-clinical evaluation. Towards a precise, subtype-specific perspective of such applications, we thought it pertinent to study its stratification into a specific molecular subtype, which would provide an accurate setting for interpretation of experimental data. Stratification of ID8 model was achieved through phenotypic, histopathological, and molecular assessment of ID8 cells grown in vitro, its primary xenografts and metastases. TME investigation of primary and metastatic tumors revealed contrasting immune populations.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell, Ovary Epithelium, Ascites Tumor Cell

DISEASE(S): Ovarian Cancer

SUBMITTER: Ritika Gupta  

LAB HEAD: Sharmila Bapat

PROVIDER: PXD060359 | Pride | 2025-10-13

REPOSITORIES: Pride