Proteomics data of plasma and bronchial alveolar lavage fluid collected from Acute respiratory distress syndrome patients

ABSTRACT: Acute respiratory distress syndrome (ARDS) is a severe and complex critical illness, characterized by its heterogeneous clinical presentation, making accurate clinical definition and effective treatment challenging. We hypothesized that advanced molecular analyses of matched plasma and bronchial alveolar lavage fluid (BALF) collected from ICU patients over the time course of their hospitalization could enable the characterization of ARDS subtypes and provide insight into the underlying mechanistic pathways, leading to novel therapeutic strategies. Proteomics and redox proteomics analyses of 32 plasma and 33 BALF specimens from 16 patients collected at serial time points generated extensive data. Applied data analytics revealed defined patient grouping for BALF, featuring distinct proteins and pathways implicated in the pathology of ARDS. Plasma analyses were much less informative. Despite the limited number of patients, this pilot study underscores the value of a molecular approach to the characterization of ARDS. As relevant biomarkers are identified and refined, we anticipate that proteomic signatures differentiating disease severity will equip clinicians with superior diagnostic tools, fostering molecularly informed treatments to ultimately improve patient outcomes.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Bronchoalveolar Lavage

DISEASE(S): Severe Acute Respiratory Syndrome

SUBMITTER: Jingyun Lee  

LAB HEAD: Cristina M. Furdui

PROVIDER: PXD060437 | Pride | 2026-02-16

REPOSITORIES: Pride