Elucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction

ABSTRACT: PTEN-WT and PTEN-4A models generation using Rosetta restrained with XL-MS crosslink distance restraints. Two major conformations of each protein were modeled

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Pten Hamartoma Tumor Syndrome

SUBMITTER: Belinda Willard  

LAB HEAD: Jennifer E Dawson

PROVIDER: PXD060469 | Pride | 2025-06-09

REPOSITORIES: Pride