A Technical Evaluation of Plasma Proteomics Technologies

ABSTRACT: We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance to lipid interference, and limit of detection/quantification. We also tested the applicability of these methods for detecting differences between healthy and cancer groups in a non-small cell lung cancer cohort.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Gallus Gallus (chicken)

TISSUE(S): Blood Plasma

SUBMITTER: Joshua Coon  

LAB HEAD: Joshua J.

PROVIDER: PXD060573 | Pride | 2025-05-12

REPOSITORIES: Pride