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Proteomic analysis of intracellular Acinetobacter baumannii replication

ABSTRACT: Ths project sought to compare the proteomic changes within murine and Acinetobacter baumannii during infections.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Nichollas Scott

LAB HEAD: Mario Feldman

PROVIDER: PXD060577 | Pride | 2026-06-15

REPOSITORIES: Pride

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			Action	DRS
	20230508_NSco-6165_MF_AB_infection_3A.raw	Raw
	20230508_NSco-6165_MF_AB_infection_3B.raw	Raw
	20230508_NSco-6165_MF_AB_infection_3C.raw	Raw
	20230508_NSco-6165_MF_AB_infection_3D.raw	Raw
	20230508_NSco-6165_MF_AB_infection_3E.raw	Raw

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Publications

Intracellular Acinetobacter baumannii acts as a transient reservoir in lung infection via a "persist and resist" strategy.

Janet-Maitre Manon M Di Venanzio Gisela G Jackson-Litteken Clay D CD Scott Nichollas E NE Feldman Mario F MF

Proceedings of the National Academy of Sciences of the United States of America 20251209 50

Although considered primarily extracellular, Acinetobacter baumannii can survive and replicate within macrophages in vitro. Intracellular bacteria are often protected from the host immune system and antibiotic treatment, potentially leading to chronic or recurrent infections. To investigate the role of intracellular A. baumannii during infection, we transferred bronchoalveolar lavage fluid (BALF) from infected mice, containing an intracellular bacterial ...[more]

PMID: 41364768

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