Improving glycosylation properties of PglS
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Escherichia Coli
SUBMITTER: 
Nichollas Scott
LAB HEAD: Christian M Harding
PROVIDER: PXD060600 | Pride | 2026-01-23
REPOSITORIES: Pride
Dataset's files
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Publications
Enhancing O-linking oligosaccharyltransferase functionality through directed evolution.
Edwards Rachel L RL McAllister Kathleen N KN McGuffey Jenna C JC Knoot Cory J CJ Hooppaw Anna J AJ Mackel Joseph J JJ Zhou Bibi B Robinson Lloyd S LS Scott Nichollas E NE Harding Christian M CM
The Journal of biological chemistry 20251105 1
Polysaccharide protein conjugate vaccines consist of bacterial polysaccharides covalently linked to carrier proteins. Bioconjugate vaccines are a type of polysaccharide protein conjugate vaccine produced by oligosaccharyltransferases, which catalyze the en bloc transfer of polysaccharides to specific amino acid motifs, called sequons, engineered into carrier proteins. The O-linking oligosaccharyltransferase PglS has been shown to have the broadest substrate repertoire, transferring virtually any ...[more]
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