Impact of TDP-43 CR Deletion on the Synaptosome Proteome of the Mouse Brain

ABSTRACT: Synaptic loss is a prominent and early pathological feature of all neurodegenerative diseases, including ALS and other TDP-43-associated neurodegenerative disorders. To investigate neuron-specific pathways affected by TDP-43 CR deletion, we conducted a quantitative mass spectrometry analysis of synaptosomes isolated from the brains of wild-type and heterozygous TDP∆CR mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Masaru Miyagi  

LAB HEAD: Masaru Miyagi

PROVIDER: PXD060626 | Pride | 2026-05-22

REPOSITORIES: Pride