Proteomics

Dataset Information

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Proteomic and phosphoproteomics analysis of triple combination therapy in cystic fibrosis


ABSTRACT: Trikafta, a CFTR modulator, is increasingly used to treat children with cystic fibrosis (CF), but its effects remain unclear. This study evaluated the cellular mechanisms of Trikafta in young children (< 11 years) with CF using a multi-omic approach. Seventeen children with CF (median age 8.4 years, 29% female) and 12 healthy controls (median age 9.6 years, 42% female) were included. Multi omics analysis including RNA sequencing, proteomics and phosphoproteomics was performed. The proteomic and phosphoproteomics data and search results a provided here. The overall results are discussed in the associated publication.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

SUBMITTER: Mark Graham  

LAB HEAD: Russell Dale

PROVIDER: PXD060637 | Pride | 2026-08-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Deamidation_NQ_Sites.txt Txt
HomoSapiensCanIso_2023_12_06.fasta Fasta
Multi-Phos.raw Raw
NP-f-02to06.raw Raw
NP-f-07to11.raw Raw
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