Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer

ABSTRACT: In the current investigation, we sought to characterize the implications of UCHL1 small molecule inhibition in both chemosensitive and chemoresistant HGSOC cells, generating an unprecedented understanding of the clinically relevant implications of targeting UCHL1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Ovarian Surface Epithelial Cell

DISEASE(S): Ovarian Serous Carcinoma

SUBMITTER: Nicholas DaSilva  

LAB HEAD: Nicole James

PROVIDER: PXD060691 | Pride | 2025-02-26

REPOSITORIES: Pride