GlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome

ABSTRACT: Immature O-glycosylation, characterized by the Tn antigen expression rather than complex glycans, is prevalent in advanced solid tumors and promotes immune evasion. We developed GlycoAvatars, magnetic beads coated with plasma-membrane glycoproteins from glycoengineered cancer cell models, to identify cancer-immune cell interactomes. Through proteomics, we propose uncovered numerous membrane and intracellular proteins involved in glycan-mediated immune signaling, providing a novel high-throughput strategy for identifying potential relevant molecular nodes foreseeing therapeutic targets.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Dendritic Cell, Macrophage

SUBMITTER: Andreia Miranda  

LAB HEAD: José Alexandre

PROVIDER: PXD060750 | Pride | 2026-09-07

REPOSITORIES: Pride