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Proteome of A7r5 rat smooth muscle cells upon uniaxial cyclic stretching with and without Chloroquine treatment

ABSTRACT: Mass spectrometry-based proteomic analysis of A7r5 rat smooth muscle cells subject to uniaxial cyclic stretching, in the presence or absence of the autophagy inhibitor Chloroquine.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Smooth Muscle Cell, Aortic Smooth Muscle Cell

SUBMITTER: Henrique Baeta

LAB HEAD: Pitter F.

PROVIDER: PXD060780 | Pride | 2026-01-30

REPOSITORIES: Pride

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			Action	DRS
	230505_A_HB_4hSTR_ALLES_CTL_1_RA1_1_8866.d.zip	Other
	230505_A_HB_4hSTR_ALLES_CTL_3_RA3_1_8868.d.zip	Other
	230505_A_HB_4hSTR_ALLES_CTL_4_RA4_1_8869.d.zip	Other
	230505_A_HB_4hSTR_ALLES_CTL_5_RA5_1_8871.d.zip	Other
	230505_A_HB_4hSTR_ALLES_CTL_6_RA6_1_8872.d.zip	Other

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Publications

Cyclic stretch induces autophagy-mediated focal adhesion remodeling and activates mitochondria.

Lövenich Lukas L Rahimi Bahareh B Baeta Henrique H Kuppusamy Maithreyan M Walkenbach Moritz M Rastfeld Frederik F Dreissen Georg G Wein Ronald R Höhfeld Jörg J Merkel Rudolf R Huesgen Pitter F PF Hoffmann Bernd B

Life science alliance 20260205 4

Mammalian cells are continuously exposed to internally generated or externally applied mechanical stimuli. Mechanosensitive proteins enable cells to sense mechanical stress and induce protective mechanisms like autophagy and cytoskeletal reorientation. However, how these contribute to cellular and tissue adaptations remains largely unknown. Here, we studied the response of rat smooth muscle cells (A7r5) to uniaxial cyclic stretch. Stretching induced autophagy and adaptive actin fiber reorientati ...[more]

PMID: 41644300

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