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Intergenerational control of ribosome levels upon dietary restriction

ABSTRACT: Living organisms adjust their proteome in response to nutritional conditions, but how these changes are transmitted across generations remains unclear. While unicellular organisms can inherit proteome states through symmetric division, multicellular organisms face limitations due to the soma-germline barrier. Using TMT-based quantitative proteomics, we investigated the intergenerational effects of dietary restriction (DR) on proteome allocation in C. elegans. While DR caused substantial proteome-wide changes within a generation, most of these changes were reset in the next generation. However, ribosomal proteins remained significantly reduced in progeny of DR mothers. This ribosomal reduction leads to an initial growth delay when encountering nutrient-rich conditions. This dataset provides a comprehensive resource to explore how proteome changes induced by DR are inherited across generations and to identify regulatory factors involved in ribosome inheritance and growth adaptation.

INSTRUMENT(S):

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Frank Stein

LAB HEAD: Benjamin Daniel Towbin

PROVIDER: PXD060999 | Pride | 2026-02-10

REPOSITORIES: Pride

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			Action	DRS
	Ernie_240628_P3289_JS_SP_TMT6_R1_FR01.raw	Raw
	Ernie_240628_P3289_JS_SP_TMT6_R1_FR02.raw	Raw
	Ernie_240628_P3289_JS_SP_TMT6_R1_FR03.raw	Raw
	Ernie_240628_P3289_JS_SP_TMT6_R1_FR04.raw	Raw
	Ernie_240628_P3289_JS_SP_TMT6_R1_FR05.raw	Raw

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Intergenerational control of ribosome levels upon dietary restriction

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