Proteomics

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Label-Free Quantitative Proteomics Study of Formalin-Fixed, Paraffin-Embedded (FFPE) Tissues in Chinese Ulcerative Colitis Patients

ABSTRACT: Five formalin-fixed, paraffin-embedded (FFPE) samples each from normal tissues and ulcerative colitis (UC) patients in China were analyzed using label-free quantitative proteomics.Comparative analysis between groups was conducted to identify differentially expressed proteins, followed by subcellular localization, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses to elucidate the protein expression profiles and molecular characteristics associated with ulcerative colitis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Bin Wang  

LAB HEAD: Huiling Wang

PROVIDER: PXD061040 | Pride | 2025-07-14

REPOSITORIES: Pride

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Publications

Comprehensive proteomic profiling of intestinal tissues in patients with ulcerative colitis.

Wang Huiling H   Xie Qi Q   Xie Yi Y   Luo Weiguang W  

Frontiers in medicine 20250613

<h4>Introduction</h4>Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colonic mucosa. This condition can significantly affect the quality of life of those affected. While UC is common, its underlying mechanisms are not yet fully understood, highlighting the need for a comprehensive proteomic analysis of intestinal tissues to identify potential biological changes associated with the disease. This study aimed to investigate the proteom  ...[more]

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