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Modification of Human MAVS protein

ABSTRACT: This modification plays a critical role in regulating protein function and cellular processes.MAVS succination sites were identified using mass spectrometry (MS). Identify succination sites of human MAVS protein.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: wenjun xia

LAB HEAD: Wenjun Xia

PROVIDER: PXD061060 | Pride | 2025-05-26

REPOSITORIES: Pride

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			Action	DRS
	MAVS-Succination-MS240222-MS.raw	Raw
	MS240222-MS.msf	Msf

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Publications

Metabolic remodelling produces fumarate via the aspartate-argininosuccinate shunt in macrophages as an antiviral defence.

Xia Wenjun W Mao Youxiang Y Xia Ziyan Z Cheng Jie J Jiang Peng P

Nature microbiology 20250418 5

Metabolic remodelling underpins macrophage effector functions in response to various stimuli, but the mechanisms involved are unclear. Here we report that viral-infection-induced inflammatory stimulation causes a rewiring of the urea cycle and the tricarboxylic acid cycle metabolism in macrophages to form a cyclic pathway called the aspartate-argininosuccinate (AAS) shunt. Using RNA sequencing, unbiased metabolomics and stable isotope tracing, we found that fumarate generated from the AAS shunt ...[more]

PMID: 40251448

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2020-06-08 | PXD019110 | Pride

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Proteomic analysis of exported chaperone/co－chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions

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2018-10-18 | PXD003789 | Pride

Identification of RNA binding proteins associated with the 5'UTR of Nrf2 during oxidative stress

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2025-06-23 | PXD055838 | Pride

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

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LC-MS/MS analysis of Gd-IgA1 and secretary TfR1 cross-linked complex

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Transcriptome analysis of ΔLMP1-MAVS transfected MARC-145 cells

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