Dataset Information

Clear Cell Renal Cell Carcinoma Serum and Tissue Proteomics

ABSTRACT: LC-MS/MS analysis was performed on tissue and serum samples from ten PDX mice derived from ccRCC tissues obtained through nephrectomy, autopsy, or biopsy, as well as six control non-PDX serum samples, and 32 normal human kidney samples. All data was collected in triplicate.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Kidney

DISEASE(S): Renal Clear Cell Carcinoma

SUBMITTER: Sharon Pitteri

LAB HEAD: Sharon Pitteri

PROVIDER: PXD061075 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	10_NHK_01.raw	Raw
	10_NHK_01.raw_20200723_Byonic_database.xlsx	Xlsx
	10_NHK_02.raw	Raw
	10_NHK_02.raw_20200723_Byonic_database.xlsx	Xlsx
	10_NHK_03.raw	Raw

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Publications

Identification of Molecular Subtypes of Clear-Cell Renal Cell Carcinoma in Patient-Derived Xenografts Using Multi-Omics.

Qiu Zhengyuan Z Zhang Dalin D Garcia-Marques Fernando Jose FJ Bermudez Abel A Zhao Hongjuan H Peehl Donna M DM Pitteri Sharon J SJ Brooks James D JD

Cancers 20250418 8

<b>Background/Objectives</b>: Clear-cell renal cell carcinoma (ccRCC) is a heterogenous disease that can be classified into multiple molecular subtypes with differential prognosis and sensitivities to treatments based on their genomic, transcriptomic, proteomic, and metabolic profiles. Patient-derived xenografts (PDXs) are high-fidelity cancer models because they maintain similar genotypes and immunohistologic phenotypes to the parental tumors and respond to standard-of-care therapies as expecte ...[more]

PMID: 40282537

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