Effects of accute depletion of Lamins on nuclear envelope-associated proteins

ABSTRACT: The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. Here, we apply the auxin-inducible degron (AID) system to rapidly deplete each lamin isoform within one cell cycle and reveal the immediate impacts of lamin loss on the nucleus.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Diploid Cell

DISEASE(S): Colon Cancer

SUBMITTER: Alexei Arnaoutov  

LAB HEAD: Mary Dasso

PROVIDER: PXD061149 | Pride | 2026-09-14

REPOSITORIES: Pride