Dataset Information

Proteomic and Phosphoproteomic Analysis of Pediatric Familial Adenomatous Polyposis

ABSTRACT: Polyps and non-polyp mucosal specimens were harvested from pediatric Familial Adenomatous Polyposis patients. The proteome and phosphoproteome of each sample was then analyzed using the tandem mass tag system on an Orbitrap Eclipse Tribrid mass spectrometer followed by data analysis with MaxQuant, ProteiNorm, proteoDA, and ProteoViz.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Dennis Province

LAB HEAD: Michael P. Washburn

PROVIDER: PXD061190 | Pride | 2026-04-27

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Experiment_MaxQuant_lysate_from_Washburn_082322_Lysate_SF01_17_others.MGF	Mgf
	Experiment_MaxQuant_lysate_from_Washburn_082322_Lysate_SF01_17_others.mzid	Mzid
	Experiment_MaxQuant_phospho_from_Washburn_082322_Phos_SF01_17_others.MGF	Mgf
	Experiment_MaxQuant_phospho_from_Washburn_082322_Phos_SF01_17_others.mzid	Mzid
	UniProt_Homo_sapiens_UP000005640_2022.08.09.fasta	Fasta

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Publications

Molecular and regional characterization of colorectal polyps: insights from proteomics, phosphoproteomics, and immune profiling.

Attard Thomas M TM St Peter Shawn D SD Kats Alexander A Lagemann Doug R DR Lawson Caitlin E CE Roy Badal C BC Yusuf Kafayat K Harvey Lisa L Bhanja Payel P Chugh Rishi Man RM Saha Subhrajit S Washburn Michael P MP Umar Shahid S

Translational gastroenterology and hepatology 20260226

<h4>Background</h4>Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer and characterized by profuse colorectal adenomas starting from the second decade of life. Regional (left <i>vs.</i> right) differences in the colonic microbiologic and immunologic microenvironment may impact adenoma evolution but are poorly understood. We aimed to characterize regional molecular, microbial, DNA damage, and immune differences in pediatric FAP polyps to test the hypothesis t ...[more]

PMID: 41969555

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