Human cancer cell proteomics identifies proteins that fail to be degraded upon treatment with a selective autophagy inhibitor

ABSTRACT: To identify the subproteome degraded by lysosomes in human cancer cells, we compared whole cell proteomes of wild-type and autophagy-deficient non-small cell lung cancer cells in the presence or absence of a lysosomal degradation inhibitor (N/L). Further, we compared whole cell proteomes of cells treated with a selective autophagy inhibitor in the presence or absence of N/L to identify lysosome substrate proteins that fail to be degraded upon treatment with this small molecule.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Simone Sidoli  

LAB HEAD: Simone Sidoli

PROVIDER: PXD061323 | Pride | 2025-05-03

REPOSITORIES: Pride